Epidemiology of Neurological Complications to Nitrous Oxide Poisoning (EPI-NOX)

Centre Hospitalier de Saint-Denis

Status: Unknown

Conditions: Neurology Department

Study type: Observational

Funder types: Other

Identifiers

NCT05329909

2022-A00718-35 (Registry Identifier)

CHSD_0023_NEURO

Details and patient eligibility

About

N2O inactivates vitamin B12, impairing its ability to act as a cofactor of methionine synthase. In addition, the elimination of vitamin B12 is increased. Neurological damage is similar to that described in combined sclerosis of the marrow, and are probably related to induce vitamin B12 deficiency. The use of N2O can then precipitate the rapid appearance of signs (neurological, psychiatric and hematological) related to a true and/ or functional vitamin B12 deficiency.

In 1978, RB Layzer described the first 3 cases of peripheral neuropathy secondary to nitrous oxide (N2O) consumption. In 2016, a team collected the 91 published cases: among these, 72 had neurological complications, and 52 had a concentration of vitamin B12 considered "low" or "normal-low"

Since then, consumption patterns seem changed due to: an increasing ease of access, the change of container (packaging in cartridge 8 grams versus bottle of 600 grams) and a usually occasional and festive consumption that seems to become solitary and regular, This change in consumption patterns is explained by an increased incidence of neurological complications, although no epidemiological work is yet available.

The objective of this work is to describe the epidemiology of this condition, to correlate it with major recent social phenomena (confinement related to the SARS-Cov2 pandemic), and finally to compare the incidence of myelopathies secondary to N2O with the incidence of other frequent inflammatory neurological diseases (autoimmune myelitis and Guillain-Barré syndrome).

Enrollment: 135 estimated patients

Sex: All

Ages: 16+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patient (≥16 years)
• Hospitalized or having consulted with the departments of Neurology or Internal Medicine for neurological phenomena related to the consumption of N2O. The neurological phenomena included are usually: neuropathies or myelopathies, However, the existence of other neurological or psychiatric signs is not a factor of exclusion: for example, headaches or cognitive or psychiatric disorders with acute onset.
• Exposure to N2O for recreational or medical reasons (Meopa anesthesia).
• Lack of alternative diagnosis other than N2O poisoning
• Consultation for neurological disorders between 01/01/2018 and 31/12/2021

Exclusion criteria

• Minor subjects or subjects subject to a legal protection measure (guardianship, curators) during the consultation.
• Refusal to include in a study explained in the file
• Absence of N2O consumption during the 6 months preceding the appearance of signs