Epidemiology of Sleep-Disordered Breathing in Adults

University of Wisconsin (UW)

Status

Active, not recruiting

Conditions

Sleep Disorders

Neurologic Disorders

Mood Disorders

Cerebrovascular Disorders

Cardiovascular Disease

Study type

Observational

Funder types

Other

NIH

Identifiers

NCT00005557

A538500 (Other Identifier)

2012-0084

SMPH/POP HEALTH SCI/POP HLTH (Other Identifier)

R01HL062252 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

To characterize the natural history and biologic spectrum of sleep disordered breathing (SDB) and other sleep problems and disorders, and test hypotheses regarding the causes and consequences of SDB and other sleep problems and disorders.

Full description

BACKGROUND:

Recent research has shown that sleep disordered breathing (SDB) is much more common than previously thought. While it is known that in clinic samples, SDB is associated with hypertension, cardiovascular disease and mortality, little is known about the natural history of this disorder, particularly in the general population, nor about the causal role of known risk factors. The knowledge obtained from the results of this study will help advance the field of sleep disorders medicine. Information about longitudinal effects and causal relationships may be applied to clinical situations, thus reducing the morbidity and mortality associated with this disorder.

DESIGN NARRATIVE:

In this longitudinal study, follow-up polysomnography and other protocols are conducted on an established cohort of men and women (age 30-60 years at the time of initial recruitment in 1989), currently enrolled in the Wisconsin Sleep Cohort Study. The study aims to : 1) describe the natural history of SDB across middle and older age; 2) investigate associations of SDB with early and intermediate markers of cardiovascular dysfunction, damage, and cardiovascular disease; 3) investigate the longitudinal association of SDB in accelerated cognitive decline; 4) investigate the association of SDB and adverse sleep characteristics with age-related risk factors and outcomes.

Enrollment

1,545 patients

Sex

All

Ages

30 to 95 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria