Epidemiology Study of Non-arteritic Anterior Ischemic Optic Neuropathy (NAION)

Viatris

Status: Completed

Conditions: Ischemic Optic Neuropathy; Anterior Ischemic Optic Neuropathy

Treatments: Other: No intervention given in this observational study

Study type: Observational

Funder types: Industry

Identifiers

NCT01260324

A1481282

Details and patient eligibility

About

The objectives of this study were to: (1) evaluate the natural history of non-arteritic anterior ischemic optic neuropathy (NAION); (2) estimate the population incidence of NAION; and (3) identify potential risk factors for NAION.

Full description

The study population consisted of members of the Ingenix Normative Health Informatics (NHI) Database during 01/01/2003 through 12/31/2007, who were 18 years of age or older with at least 183 days of continuous enrollment in the database and without any doctor visits associated with a diagnosis of ischemic optic neuropathy during the 183 days prior to cohort entry.

From the study population, patients with a claim associated with an ischemic optic neuropathy diagnosis code were identified as potential NAION cases (n = 3,732). From the potential NAION cases, definite and possible NAION cases were identified using medical record review and a claims algorithm (n=1,283).

From the study population, patients without a claim associated with an ischemic optic neuropathy diagnosis code were randomly selected as controls (n = 20,000)

Enrollment: 21,283 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Member of the Ingenix Normative Health Informatics (NHI) Database during 01/01/2003 through 12/31/2007
• 18 years of age or older
• Had at least 183 days of continuous enrollment in the database
• No doctor visits associated with a diagnosis of ischemic optic neuropathy during the 183 days prior to cohort entry

Exclusion criteria

• Less than 18 years of age
• Less than 183 days of continuous enrollment in the database
• At least one doctor visit associated with a diagnosis of ischemic optic neuropathy during the 183 days prior to cohort entry

Trial design

21,283 participants in 2 patient groups

NAION cases

Description:

From the study population, patients with a claim associated with an ischemic optic neuropathy diagnosis code were identified as potential NAION cases (n = 3,732). From the potential NAION cases, definite and possible NAION cases were identified using medical record review and a claims algorithm (n=1,283). Data from definite and possible NAION cases contributed to the analysis.

Treatment:

Other: No intervention given in this observational study

Other: No intervention given in this observational study

Controls

Description:

From the study population, patients without a claim associated with an ischemic optic neuropathy diagnosis code were randomly selected as controls (n = 20,000)

Treatment:

Other: No intervention given in this observational study

Other: No intervention given in this observational study