Epidural Analgesia (EDA) Versus Patient Controlled Analgesia (PCA) in Laparoscopic Colon Surgery (EVA)

Lausanne University Hospital (CHUV)

Status: Completed

Conditions: Laparoscopic Colectomy

Treatments: Procedure: Epidural analgesia; Procedure: Patient controlled analgesia

Study type: Interventional

Funder types: Other

Identifiers

NCT00508300

P166/07

Details and patient eligibility

About

The purpose of this study is to determine whether a epidural analgesia versus patient controlled analgesia reduces the medical recovery in patients undergoing elective laparoscopic colon surgery.

Full description

Allocation by individual random number generated by a computer program to either EDA or PCA for 48h after laparoscopic colonic surgery.

Short, both groups are treated according to a recent Fast track protocol. Group A will preoperatively receive a mid thoracic EDA (th 8-9; naropine 0,1%) while group B will receive a PCA (morphine) postoperatively. Both EDA and PCA are removed the afternoon at day 2. Patients with a non-functioning EDA within the first 24h will be crossed over to the PCA group.

Enrollment: 128 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients admitted for elective laparoscopic colonic surgery

Exclusion criteria

• Age < 18y
• No informed consent
• Emergency situation
• Contraindication for EDA (according to local Anesthesia guidelines)

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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128 participants in 2 patient groups

A

Other group

Description:

Epidural Analgesia (EDA) An epidural catheter was inserted at thoracic level (Th8-Th10) before induction of anesthesia. A bolus of 5 mL of bupivacaine 0.5% was started as soon as the epidural catheter was in place, and a continuous perfusion of bupivacaine 0.5% at 5 mL/hr was initiated until the end of surgical procedure.

Treatment:

Procedure: Epidural analgesia

B

Other group

Description:

Patient controlled analgesia (PCA) was assured by fentanyl (morphine-based) as needed.

Treatment:

Procedure: Patient controlled analgesia