Epigenetic Effects of a Single Bout of Exercise on Cardiovascular Risk Factors and the Metabolome

University of North Carolina System

Status

Completed

Conditions

Obesity

Cardiovascular Diseases

Type 2 Diabetes

Acute Exercise

Treatments

Behavioral: Acute exercise

Study type

Interventional

Funder types

Other

Identifiers

NCT05034380

AcuteExerciseNucleo

Details and patient eligibility

About

The purpose of this study is to determine the ability of acute exercise to regulate fat metabolism in muscle of overweight and obese people compared to lean people.

Full description

After being informed about the study details and possible risks and benefits, 15 overweight/obese and 15 lean participants gave written informed consent and were then screened and enrolled in the study. All participants then gave a muscle sample and ate a calorically controlled breakfast. Participants completed ~1 hour of cycling exercise on a stationary bike and gave a second muscle sample 4 hours after eating breakfast.

Enrollment

30 patients

Sex

Male

Ages

18 to 30 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

healthy males that completed a physical examination with a State Licensed M.D. or D.O. within the past 2 years and completed a physical activity readiness questionnaire (PARQ), the International Physical Activity Questionnaires (IPAQ) and and a medical history questionnaire prior to the study

Exclusion criteria

any participants that had not had a physical examination by a State Licensed M.D. or D.O. within the past 2 years
persons not considered "healthy" (with any previous medical diagnoses) or not medically cleared by a M.D. or D.O. to perform physical activity/exercise
persons who are regularly physically active