Epigenetics Based Diagnosis of Diabetes in Saliva and Blood Samples

Medical University of Vienna

Status: Unknown

Conditions: Ectopic Lipids; Prediabetic State; Epigenetics Based Modifications; Diabetes Mellitus, Type 2

Treatments: Diagnostic Test: Blood sampling; Diagnostic Test: Magnet Resonance Spectroscopy; Diagnostic Test: Saliva and blood samples

Study type: Observational

Funder types: Other

Identifiers

NCT04011228

EPI-1090

Details and patient eligibility

About

The aim of the present study is to investigate epigenetics based modifications and biomarkers in the saliva and blood in diabetic patients.

Enrollment: 224 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• type 2 diabetic patients
• prediabetic patients
• women with gestational diabetes
• healthy control subjects without diabetes
• healthy pregnant women

Exclusion criteria

• cancer disease
• infectious diseases such as hepatitis or HIV
• malignoms
• patients with claustrophoby

Trial design

224 participants in 5 patient groups

Type 2 diabetic patients

Treatment:

Diagnostic Test: Magnet Resonance Spectroscopy

Diagnostic Test: Blood sampling

Diagnostic Test: Saliva and blood samples

Prediabetic patients

Treatment:

Diagnostic Test: Magnet Resonance Spectroscopy

Diagnostic Test: Blood sampling

Diagnostic Test: Saliva and blood samples

Women with gestational diabetes

Treatment:

Diagnostic Test: Magnet Resonance Spectroscopy

Diagnostic Test: Blood sampling

Diagnostic Test: Saliva and blood samples

Healthy control subjects

Treatment:

Diagnostic Test: Magnet Resonance Spectroscopy

Diagnostic Test: Blood sampling

Diagnostic Test: Saliva and blood samples

Pregnant women without gestational diabetes

Treatment:

Diagnostic Test: Magnet Resonance Spectroscopy

Diagnostic Test: Blood sampling

Diagnostic Test: Saliva and blood samples