Epigenetics in Lupus Nephritis (Epi_LN)

University of Göttingen

Status: Unknown

Conditions: Lupus Nephritis; Systemic Lupus Erythematosus

Treatments: Diagnostic Test: Blood sampling

Study type: Observational

Funder types: Other

Identifiers

NCT04648059

28/9/17

Details and patient eligibility

About

This is a translational study for the identification of epigenetic changes detectable in sera of patients suffering from Systemic Lupus erythematosus. The aim of the study is to analyze whether circulating DNA fragments are 1) different in patients with or without Lupus nephritis and 2) present and detectable in the circulation before the development of Lupus nephritis.

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of systemic lupus erythematosus according to the current classification criteria
• a subgroup requires the presence of Lupus nephritis (no restriction to specific LN histologic subtypes)

Exclusion criteria

• patients not able or unwilling to provide written informed consent

Trial design

60 participants in 2 patient groups

Lupus nephritis +ve

Description:

This group consists of patients with Lupus nephritis

Treatment:

Diagnostic Test: Blood sampling

Lupus nephritis -ve

Description:

This group consist of patients with SLE without Lupus nephritis

Treatment:

Diagnostic Test: Blood sampling