Epileptic Seizure in Epilepsy Patients After SARS-CoV-2 Vaccination

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Vaccine Adverse Reaction; Epileptic Seizures Related to Drugs; SARS-CoV-2 Acute Respiratory Disease

Treatments: Biological: inactive SARS-Cov-2 vaccine

Study type: Observational

Funder types: Other

Identifiers

NCT05341713

KY20222046-C-1

Details and patient eligibility

About

Background and Objectives: Seizure attack is one of adverse effects of vaccination in epileptic patients, the risk of which after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inoculation was elucidated in the present study.

Methods: A self-controlled case series study was designed to examine the association between vaccination and epileptic seizure. A total of 240 epilepsy patients were included who were vaccinated with inactive SARS-CoV-2 vaccines (Sinovac Life Sciences and Lanzhou Institute of Biological Products) and admitted to outpatient clinics from July 2021 to December 2021. Poisson analysis was performed to estimate the relative incidence rate of epileptic seizure in risk periods (day 1-7, 8-21 and 1-21 after first-dose vaccination) compared to basal level in control period.

Enrollment: 240 patients

Sex: All

Ages: 3+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Male or female participants
• Have a diagnosis of epilepsy by the end of the study
• Have received at least one dose of inactive SARS-Cov-2 vaccine (Sinovac Life Sciences and Sinopharm Group)

Exclusion criteria

• Non-epilepsy patients vaccinated with inactive SARS-Cov-2 vaccine
• Epilepsy patients administrated with non-inactive vaccine
• Unvaccinated epilepsy patients