Epileptogenic Focus Localization for Children With Epilepsy Using 18F-FDG PET Molecular Imaging

Zhejiang University

Status: Completed

Conditions: Epilepsy

Treatments: Radiation: 18F-FDG

Study type: Observational

Funder types: Other

Identifiers

NCT04725162

2020-862

Details and patient eligibility

About

This retrospective study aimed to develop a new approach for automatic localization of epilepsy foci in children with epilepsy.

Full description

This retrospective study aimed to develop a new approach for automatic localization of epilepsy foci in children with intractable epilepsy.

Pediatric patients with intractable epilepsy would be retrospectively included in this study. The inclusion criteria included (1) age between 6 and 18 y; (2) detailed seizure semiology evaluation, MRI, EEG and interictal 18F-FDG PET/CT examination; (3) clinical diagnosis as focal epilepsy. The exclusion criteria included (a) any history of central nervous system disease; (b) poor image quality due to head movement.

Enrollment: 234 patients

Sex: All

Ages: 6 to 18 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. age between 6 and 18 years.
• 2. detailed presurgical evaluation, including seizure semiology evaluation, MRI, EEG and interictal 18F-FDG PET/Computer Tomography (CT) examination.
• 3. clinical diagnosis as focal epilepsy.

Exclusion criteria

• 1. any history of central nervous system (CNS) disease such as trauma and CNS tumor.
• 2. poor image quality due to head movement.

Trial design

234 participants in 3 patient groups

Epilepsy patients

Description:

Pediatric patients with focal epilepsy.

Treatment:

Radiation: 18F-FDG

Control

Description:

Age-matched controls who underwent 18F-FDG PET/CT examination for diseases outside brains.

Treatment:

Radiation: 18F-FDG

Validation

Description:

Children who underwent 18F-FDG PET/MRI to examine extracranial tumors.

Treatment:

Radiation: 18F-FDG