Episodic Memory Before and After Surgery in Drug-resistant Partial Epilepsies (MemO-Epi)

Institut National de la Santé Et de la Recherche Médicale, France

Status: Unknown

Conditions: Memory Impairment; Epilepsy, Unspecified, Pharmacologically Resistant

Treatments: Other: No intervention

Study type: Interventional

Funder types: Other

Identifiers

NCT01919957

C12-11

2013-A00343-42 (Registry Identifier)

Details and patient eligibility

About

This study has two purposes: firstly, a better understanding of the neurobiological processes underlying episodic memory and, secondly, the development of useful clinical applications for epileptic patients, in particular the prediction of postoperative memory deficits and the development of cognitive remediation therapies.

Memory performances during a fMRI experiment will be assessed in controls and epileptic patients before and after the surgery.

Enrollment: 120 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients with drug-resistant epilepsy
• Age of 18 years or more
• Follow-up in the epilepsy unit at Pitié-Salpêtrière Hospital
• Before or after the presurgical evaluation unit including a video-EEG monitoring, a structural brain imaging and a full neuropsychological assessment
• Covered by a social security system
• Signing of consent form

Exclusion criteria

• Persons under guardianship, curatorship or any other administrative or judicial deprivation of rights and freedom
• Refusal to consent form
• Contraindications to MRI
• Pregnancy
• Refusal to be informed in the case of detection of an abnormality during the experiment

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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120 participants in 1 patient group

memory outcome

No Intervention group

Treatment:

Other: No intervention