Epithelial Damage in GERD

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Gastro-esophageal Reflux Disease

Study type: Observational

Funder types: Other

Identifiers

NCT01867931

NL39721.068.12

Details and patient eligibility

About

The purpose of this study is to characterize and compare epithelial damage in patients with erosive esophagitis and non-erosive reflux disease.

Enrollment: 34 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Typical GERD-symptoms lasting for more than 6 months (recurrent episodes of heartburn or acid regurgitation)
• abnormal pH-parameters (pathological acid exposure and/or symptom association)

Exclusion criteria

• Age <18 years
• Previous esophageal or gastric surgery
• Severe esophageal motility disorder on manometry
• Histological evidence of Barrett's mucosa
• Severe co-morbidities (including cardiopulmonary disease, portal hypertension, collagen diseases, morbid obesity, coagulation disorders and co-morbidity hindering a gastroscopic procedure)
• Use of anticoagulant or immunosuppressive drugs
• Inability to stop medication that can influence the test results, like PPI, for at least 10 days before tests
• Excessive alcohol consumption (>20 units per week)
• Patients unable to give informed consent.

Trial design

34 participants in 3 patient groups

Erosive Esophagitis

Non-erosive Reflux Disease

Heatlhy volunteers