EPO for Postop Delirium in Elderly Patients
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About
Postoperative delirium is a common complication after surgery. The underlying pathophysiology of this complication is unclear, however neuroinflammation and oxidative stress secondary to surgery had shown to be the cause of postoperative cognitive dysfunction and delirium. Erythropoietin represents non-erythropoietic effects of anti-inflammatory properties. The aims of this study were to determine the role of erythropoietin toward the development of postoperative delirium, in terms of changes in inflammatory reaction by affecting the innate immunity in elderly patients undergoing total joint arthroplasty surgery.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Age 65 years and older
- Patients scheduled for elective total knee arthroplasty, total hip arthroplasty
Exclusion criteria
- Unable to communicate
- Cognitive impairment
- Unable to pre-screen delirium due to underlying central nervous system disease
- History of hypersensitivity related to erythropoietin and other anesthesia-related drugs
- History of myocardial infarction, pulmonary infarction, cerebral infarction, ischemic vascular disease, epilpesy, chronic liver disease, chronic kidney disease
- Uncontrolled high blood pressure
- Within one month of starting anti-hypertensive medication
Trial design
Primary purpose
Allocation
Interventional model
Masking
76 participants in 2 patient groups, including a placebo group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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