Epstein-Barr Virus and Cancer Risks (EBVCR)

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Sun Yat-sen University

Status

Enrolling

Conditions

Cancer

Treatments

Other: Diagnostic test: EBV antibody tests

Study type

Observational

Funder types

Other

Identifiers

NCT06203314
EBV-PRO-001

Details and patient eligibility

About

The goal of this prospective cohort study is to investigate the associations between Epstein-Barr Virus (EBV) antibody levels and the risk of overall and site-specific cancer types in Southern China. The main questions it aims to answer are: Question 1: In addition to the established EBV-associated cancer types, such as lymphomas, nasopharyngeal carcinoma, and stomach cancer, whether EBV is associated with other cancer types? Question 2: What's the cancer burden attributed to EBV in Southern China?

Full description

Growing molecular evidence suggests the involvement of EBV in various cancers, however, comprehensive epidemiological evidence is still lacking. In this study, researchers conducted a population-based prospective cohort study to investigate the associations between EBV antibodies and the risk of overall and site-specific cancer types in Southern China. All the participants underwent EBV antibody tests at enrollment and were subsequently followed up annually for cancer incidence, vital status, and immigration status. The primary objective of this study was to provide prospective evidence for the role of EBV in multiple cancers, shedding light on the etiology of a broad range of common EBV-associated cancers.

Enrollment

100,000 estimated patients

Sex

All

Ages

30 to 69 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Subject residents in Zhongshan or Wuzhou City;
  • Subject has no medical record of prevalent cancer;
  • Subject has psychical condition and well consciousness, and willingness to accept and cooperate with the study's follow-up procedures.

Exclusion criteria

  • Subject has heavy cardiovascular, liver, or kidney disease;
  • Subject has prevalent cancer.

Trial design

100,000 participants in 2 patient groups

Zhongshan cohort, Guangdong, China
Description:
30-59 years old healthy participants in Zhongshan city.
Treatment:
Other: Diagnostic test: EBV antibody tests
Wuzhou cohort, Guangxi, China
Description:
30-69 years old healthy participants in Wuzhou city.
Treatment:
Other: Diagnostic test: EBV antibody tests

Trial contacts and locations

2

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Central trial contact

Wei-Hua Jia; Yong-Qiao He

Data sourced from clinicaltrials.gov

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