Epstein-Barr Virus Status in Diffuse Large B Cell Lymphoma

Samsung Medical Center

Status

Completed

Conditions

Diffuse Large B-cell Lymphoma

Treatments

Other: EBER

Study type

Observational

Funder types

Other

Identifiers

NCT02060435

2013-07-101-001

Details and patient eligibility

About

The investigators analyzed clinical outcome in DLBCL patients according to age group to define the impact of EBV status on the clinical outcome.

Full description

Epstein-Barr virus (EBV) positive diffuse large B-cell lymphoma (DLBCL) has been recognized as a new provisional entity in the 2008 World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissue. This lymphoma is defined as EBV+ clonal B-cell proliferation in immunocompetent adults older than 50 years. To denote patient age in definition of this disease, age cutoff was defined as older than 50 years. However, this cutoff is clearly arbitrary without any scientific background. the knowledge on EBV+DLBCL in young adult is very scanty. This EBV+DLBCL in young adult can be the same disease entity or it can be a distinct disease form EBV+DLBCL of elderly.

Enrollment

571 patients

Sex

All

Ages

17 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Pathologically confirmed de novo DLBCL, according to the World Health Organization (WHO) classification:
- registered in Samsung Medical Center (SMC) Lymphoma Cohort Study I/II (ClinicalTrials.gov Identifier: NCT00822731, NCT01877109) or identified from Asan Medical Center (AMC) medical database:
- adequate amount and quality of paraffin-embedded biopsy specimen or unstained slides for EBV-encoded RNA (EBER) in situ hybridization.

Exclusion criteria

Patients with unknown EBV status, primary central nervous system (CNS) lymphoma, post-transplant lymphoproliferative disorders (PTLDs), and HIV-positive DLBCL were excluded in the study.