Erasme Randomized Controlled Trial Surveys Hemodynamic Excursions During Esophagectomy (ERASME ULB)

Free University of Brussels (ULB)

Status

Not yet enrolling

Conditions

Hemodynamic Instability

Esophagectomy

Paravertebral Anesthesia

Epidural; Anesthesia

Treatments

Other: Hemodynamic changes between epidural and paravertebral during esophagectomy

Study type

Interventional

Funder types

Other

Identifiers

NCT06563557

P2023/514 /B4062024000032

Details and patient eligibility

About

In our high volume center, the majority of esophagectomy procedures are performed with minimally invasive techniques. The thoracic epidural technique remains the gold standard and homolateral paravertebral catheter is strongly recommended. The vasoplegia and sympathetic blockade due to the epidural can cause significant hypotension especially as reverse Trendelenburg position is required during surgery. The aim is to study hemodynamic changes caused by two different techniques. Previous studies found a similar pain management between both locoregional techniques, however few studies suggested less side effects in the paravertebral group during major abdominal surgeries.

Enrollment

75 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adult, Capable of giving consent, two or three incisions esophagectomy (thoracoscopic/ thoracotomy) no laparotomy

Exclusion criteria

patient refusal, total language barrier, coagulation disorders, thrombocytopenia <75 000, contraindications to locoregional anesthesia (infection local site, allergy to local anesthesic), scoliosis Cobb > 45%, atrial fibrillation, end stage renal disease),