ERCP in Super-aged Patients Considering Difficult Cannulation: Challenges and Adverse Events

Nanjing Medical University

Status: Completed

Conditions: Cholangitis; Post-ERCP Acute Pancreatitis

Treatments: Diagnostic Test: ERCP

Study type: Observational

Funder types: Other

Identifiers

NCT03771547

DC-0918

Details and patient eligibility

About

Today 11 percent of China's population is over the age of 65, and according to United Nations, it will take China just 20 years for the proportion of the elderly population to double to 25%. As life expectancy has increased, application of Endoscopic Retrograde Cholangiopancreatography (ERCP) in super-aged (≥80 years of age) is no longer limited with increasing prevalence of choledocholithiasis, and malignancy in advancing age. This increasing may come with more difficulty in cannulation or more complications in senior patients. Regarding difficult cannulation, little is known about grading difficulty in the elderly and its relation with adverse events. Therefore, it is time to evaluate the risk factors of adverse events in super-aged patients with difficult bile duct cannulation.

Full description

AIM: To evaluate the incidence, causes, and management of difficult biliary cannulation during ERCP in elderly patients and its role as a risk factor for adverse events.

METHODS: A total of 614 patients, with a mean age of 65.3±16.7 years, underwent ERCP during the study period, were prospectively managed and divided into two groups based on their age. There were 146 patients aged 80 years or older in group A with the mean age of 84±3.4 years. The primary outcome measurements were the difficulty grade of papilla cannulation, clinical outcomes, and ERCP-related complications in the two groups. The adverse events were analyzed by logistic regression about patient age, co-morbidities, indications, and difficult cannulation grading.

Enrollment: 614 patients

Sex: All

Ages: 16 to 94 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who underwent ERCP between July 2016 and January 2018.

Exclusion criteria

• We excluded the patients who underwent ERCP for the objectives of follow up, stent removing or taking a biopsy.

Trial design

614 participants in 2 patient groups

More 80

Description:

The first group included ERCP patients aged 80 and above.

Treatment:

Diagnostic Test: ERCP

Less 80

Description:

The second group included those ERCP patients younger than 80.

Treatment:

Diagnostic Test: ERCP