Erector Spinae Versus Intercostal Nerve Blocks With Liposomal Bupivacaine for Analgesia in Thoracic Surgery

George Washington University (GW)

Status and phase: Enrolling; Phase 3

Conditions: Lung Cancers

Treatments: Drug: Erector Spinae (ESP) Block with Bupivacaine (Marcaine®); Drug: Intercostal nerve block

Study type: Interventional

Funder types: Other

Identifiers

NCT06810375

NCR246143

Details and patient eligibility

About

This clinical trial compares efficacy in postoperative pain management in thoracic surgery between erector spinae block versus liposomal bupivacaine injections.

Enrollment: 120 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Video assisted pulmonary resection, pleurodesis or decortication

Exclusion criteria

• Allergy to local anesthetics
• Patient undergoing bilateral surgery
• Surgery is emergent as deemed by the principal investigator

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Preoperative Erector Spinae Block (ESB)(Bupivacaine)(Marcaine®)

Active Comparator group

Treatment:

Drug: Intercostal nerve block

Drug: Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)

Intraoperative Intercostal Nerve Block (INB)(Liposomal Bupivacaine)(Exparel®)

Active Comparator group

Treatment:

Drug: Intercostal nerve block

Drug: Erector Spinae (ESP) Block with Bupivacaine (Marcaine®)