Erlotinib and Radiation Therapy in Treating Older Patients With Stage I, Stage II, Stage III, or Stage IV Esophageal Cancer

Roswell Park Comprehensive Cancer Center

Status and phase

Completed

Phase 2

Conditions

Esophageal Cancer

Treatments

Other: immunohistochemistry staining method

Drug: erlotinib hydrochloride

Radiation: radiation therapy

Study type

Interventional

Funder types

Other

Identifiers

NCT00524121

CDR0000563268

RPCI-I-62705 (Other Identifier)

Details and patient eligibility

About

RATIONALE: Erlotinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high-energy x-rays to kill tumor cells. Giving erlotinib together with radiation therapy may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving erlotinib together with radiation therapy works in treating older patients with stage I, stage II, stage III, or stage IV esophageal cancer.

Full description

OBJECTIVES:

Primary

Assess the overall survival of older patients with stage I-IV squamous cell carcinoma or adenocarcinoma of the esophagus or gastroesophageal junction treated with erlotinib hydrochloride in combination with radiotherapy.

Secondary

Assess the proportion of patients achieving mucosal complete response after treatment with this regimen.
Determine the progression-free survival of patients treated with this regimen.
Assess the effect of this regimen on dysphagia control, performance status, and overall quality of life of these patients.
Investigate the correlation between smoking status and overall survival of these patients.
To correlate the Epidermal growth factor receptor (EGFR) and phosphor Epidermal growth factor receptor (pEGFR) expression by IHC and EGFR mutation status with clinical outcomes.

OUTLINE: This is a multicenter study.

Patients receive oral erlotinib hydrochloride once daily for 1 year in the absence of disease progression or unacceptable toxicity. Patients undergo external beam radiotherapy 5 days a week in weeks 1-4 or 5 days a week for the first 5.5 weeks.

Tumor tissue samples are analyzed by IHC for the expression of E-cadherin, P-cadherin, vimentin, cytokeratin, phospho-S6, and Ki67.

After completion of study treatment, patients are followed at 30 days and annually thereafter.

Enrollment

22 patients

Sex

All

Ages

65 to 120 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

DISEASE CHARACTERISTICS:

Biopsy-proven primary squamous cell carcinoma or adenocarcinoma of the esophagus or gastroesophageal (GE) junction
- GE junction tumors with 50% or more tumor located in the esophagus determined by radiologic or endoscopic evaluation
- Stage I-IVA disease determined by CT scan or MRI of the chest and abdomen
  - Stage IVB disease allowed if metastases to distant regional lymph nodes (celiac or cervical) only and no other sites
Not a surgical candidate and ineligible for chemotherapy due to any of the following:
- Neuropathy
- Cardiac disease
- Performance status 2
- General overall condition felt by the investigator to be a contraindication to platinum-based therapy
Bronchoscopy with biopsy and cytology required if primary esophageal cancer is < 26 cm from incisors
No evidence of clinically active interstitial lung disease (patients who are asymptomatic with chronic, stable, radiographic lung changes allowed)

PATIENT CHARACTERISTICS:

ECOG performance status 0-2
Life expectancy > 4 months
WBC ≥ 3,000/mm³
ANC ≥ 1,500/mm³
Platelet count > 100,000/mm³
Bilirubin ≤ 1.3 mg/dL
ALT and AST ≤ 2.5 times upper limit of normal (ULN)
Alkaline phosphatase ≤ 2.5 times ULN
No prior malignancies except basal cell or squamous cell skin cancer, in situ cervical cancer, or superficial transitional cell bladder cancer, unless diagnosed and/or treated > 2 years prior to current study and are without evidence of recurrence
No history of allergy to erlotinib or any of its excipients
No serious, uncontrolled, concurrent infection
No clinically serious, uncontrolled medical conditions that the investigator feels might compromise study participation
No lack of physical integrity of the upper gastrointestinal tract or malabsorption syndrome
No unwillingness to participate or inability to comply with the protocol for the duration of the study

PRIOR CONCURRENT THERAPY:

No prior chemotherapy or radiotherapy for this tumor
No prior resection or attempted resection of esophageal cancer
No prior anti-epidermal growth factor receptor therapy (unless given in an adjuvant setting and completed at least 12 months earlier)
No participation in any investigational drug study within the past 4 weeks
No HIV-positive patients receiving antiretroviral therapy
No concurrent CYP3A4/5 inducers or inhibitors