Erythropoietin - Albumin Platelet-rich Fibrin in Transcrestal Sinus Lifting With Simultaneous Implant Placement

Alexandria University

Status: Enrolling

Conditions: Sinus Lifting

Treatments: Other: Erythropoietin and albumin PRF gel + implant placement; Other: Albumin PRF gel +implant placement

Study type: Interventional

Funder types: Other

Identifiers

NCT07150858

1073-5/2025

Details and patient eligibility

About

Background: Dental implant therapy in the posterior maxilla may be difficult owing to limited bone height after dental extraction with sinus pneumatization. Several approaches for sinus floor elevation have been documented, and hence trans crestal sinus lifting with albumin platelet rich plasma.

Aim of the study: To compare between erythropoietin and albumin platelet rich fibrin transcrestal sinus lifting versus albumin platelet rich fibrin transcrestal sinus lifting using piezoelectric device in patients with atrophic maxilla.

Methods: This study will be carried out as a randomized

Enrollment: 20 estimated patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Residual bone height not less than 5 mm measured from crestal bone to sinus floor.
• Both genders.
• Good oral hygiene
• No previous surgery or radiation treatment on the maxillary sinus

Exclusion criteria

• Recent radiation therapy in maxilla.
• Uncontrolled systemic diseases such as diabetes mellitus.
• Heavy smoker (those who smoke ≥ 25 cigarettes a day).
• Alcohol abuse.
• Patient on anticoagulant drug
• Severe allergic rhinitis.
• Tumor or large cyst in the maxillary sinus.
• Oroantral fistula.
• Presence of acute or chronic sinus pathoses or sinus membrane perforation.(

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

Erythropoietin and albumin PRF gel

Experimental group

Treatment:

Other: Erythropoietin and albumin PRF gel + implant placement

albumin PRF gel

Active Comparator group

Treatment:

Other: Albumin PRF gel +implant placement