ESBL in Patients Returning to Sweden With Traveller's Diarrhoea

Lund University

Status: Completed

Conditions: Antibiotic Resistant Infection; Antibiotic Resistant Strain; Traveler's Diarrhea

Treatments: Other: No intervention, observational

Study type: Observational

Funder types: Other

Identifiers

NCT03866291

2017-0123

Details and patient eligibility

About

Patients with traveller's diarrhoea frequently harbour Extended Spectrum Betalactamase (ESBL)-producing Enterobacteriaceae (EPE) returning from EPE-endemic areas.

This study investigates to what extent travellers returning to Sweden with traveller's diarrhoea carry ESBL in their stool. The isolates are examined further according to species, phenotype, antibiogram and whole genome sequencing.

Full description

Samples sent to the department of clinical microbiology in Lund, Sweden for culture of salmonella, shigella, yersinia or campylobacter are also cultured selectively for ESBL.

All patients are contacted by mail with the results. ESBL-positive patients are invited to submit further faecal cultures and blood samples during one year follow up time, to investigate how long the patient is colonized with ESBL.

Enrollment: 305 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Travellers diarrhoea
• foreign traveller

Exclusion criteria

• foreign traveller but no symptoms

Trial design

305 participants in 2 patient groups

ESBL carrier

Description:

This cohort is followed for a year with additional selective ESBL cultures after 1, 3, 6 and 12 months. In the end of the year a questionnaire is handed in to the study group. Sera is donated after 4-6 weeks and in year.

Treatment:

Other: No intervention, observational

Non ESBL-carrier

Description:

No further rectal cultures. In the end of the year a questionnaire is handed in to the study group. Sera is donated after 4-6 weeks and in year.

Treatment:

Other: No intervention, observational