Esketamine Administration on Recovery Quality After Radical Mastectomy

Anqing Municipal Hospital

Status: Completed

Conditions: Esketamine and the Quality of Recovery

Treatments: Drug: High-dose esketamine infusion; Drug: Low-dose esketamine infusion; Drug: Saline infusion

Study type: Interventional

Funder types: Other

Identifiers

NCT05289440

Zhumin

Details and patient eligibility

About

Some studies have reported that intravenous esketamine reduce postoperative pain intensity. The investigators investigated whether esketamine could improve the the quality of recovery after modified radical mastectomy.

Full description

A total of 111 patients were randomly allocated into 3 groups. Patients in group LE received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 2 µg/kg/min until before suture the skin. Patients in group HE received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 4 µg/kg/min until before suture the skin. Patients in group CON received a bolus infusion of the same volume saline before cutting the skin, and then the same volume saline was infused until before suture the skin.

Enrollment: 105 patients

Sex: Female

Ages: 30 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists (ASA) physical status
• Scheduled for elective modified radical mastectomy

Exclusion criteria

• Severe respiratory disease
• Renal or hepatic insufficiency
• History of preoperative psychiatric
• Preoperative hypertension
• Preoperative history of chronic pain

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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105 participants in 3 patient groups

Low-dose esketamine infusion on the quality of recovery after radical mastectomy

Experimental group

Description:

Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 2 µg/kg/min until before suture the skin.

Treatment:

Drug: High-dose esketamine infusion

Drug: Saline infusion

Drug: Low-dose esketamine infusion

High-dose esketamine infusion on the quality of recovery after radical mastectomy

Experimental group

Description:

Patients received a bolus infusion of esketamine (0.5 mg/kg) before cutting the skin, and then esketamine was infused at a rate of 4 µg/kg/min until before suture the skin.

Treatment:

Drug: High-dose esketamine infusion

Drug: Saline infusion

Drug: Low-dose esketamine infusion

Saline infusion on the quality of recovery after radical mastectomy

Experimental group

Description:

Patients received a bolus infusion of the same volume saline before cutting the skin, and then the same volume saline was infused until before suture the skin.

Treatment:

Drug: High-dose esketamine infusion

Drug: Saline infusion

Drug: Low-dose esketamine infusion