Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery

Loma Linda University (LLU)

Status: Completed

Conditions: Hypertension

Treatments: Drug: nitroglycerin; Drug: esmolol

Study type: Interventional

Funder types: Other

Identifiers

NCT01212874

5100218

Details and patient eligibility

About

This is an investigator initiated, sponsored, open label, prospective randomized controlled trial to be performed in adult patients undergoing scheduled cardiac surgery. Patients will be randomized to esmolol infusion or nitroglycerin infusion for control of hypertension that occurs during cardiac surgery from induction of anesthesia to initiation of cardiopulmonary bypass (CPB).

Enrollment: 70 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients scheduled for cardiac surgery at LLUMC University Hospital will be eligible for participation in this study.

Exclusion criteria

1. severe LV (left ventricle)dysfunction (EF < 35%).
2. emergency procedures.
3. procedures with combined carotid artery surgery.
4. patients at high risk for stroke.
5. hemodynamically significant dysrhythmias.
6. pre-existing atrial fibrillation or high degree AV (atrioventricular block).
7. pacemaker dependency.
8. known sensitivity to beta blockers.
9. patient refusal.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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70 participants in 2 patient groups

Nitroglycerin

Active Comparator group

Description:

nitroglycerin titrated to control hypertension between anesthesia induction and initiation of cardiopulmonary bypass

Treatment:

Drug: nitroglycerin

Esmolol

Active Comparator group

Description:

esmolol titrated to control hypertension between anesthesia induction and initiation of cardiopulmonary bypass

Treatment:

Drug: esmolol