Esophageal Absorption in EoE

Mayo Clinic

Status: Terminated

Conditions: Eosinophilic Esophagitis

Treatments: Other: D-xylose

Study type: Interventional

Funder types: Other

Identifiers

NCT02314455

13-009092

Details and patient eligibility

About

To determine how the esophagus in active and inactive stages of eosinophilic esophagitis tranmit fluids.

Enrollment: 14 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a combination of compatible symptoms, endoscopic findings, histology, and lack of response to proton pump inhibitors or negative pH study
• endoscopy with esophageal and duodenal biopsies within two weeks of performance of this study
• Patients between the ages of 18 and 80 with eosinophilic esophagitis diagnosed by a combination of compatible symptoms, endoscopic findings, histology, and lack of response to proton pump inhibitors or negative pH study, and are now in histologic remission( <15phf) by the use of steroids or the six food elimination diet.
• Volunteers will be selected for not having any history of esophageal symptoms

Exclusion criteria

• Vulnerable populations, such as those with diminished mental acuity, will be excluded.
• Patients taking Nsaids within 48 hours of the d-xylose testing
• artificial sweeteners within 48 hours of the d-xylose testing
• History of IBD
• Currently smoking or history of smoking
• History of Celiac disease
• Bacterial overgrowth,
• motility disorders
• other diffuse small bowel diseases.

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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14 participants in 1 patient group

D-xylose, water, honey

Experimental group

Description:

* 25 grams of D-xylose * 10 cc of water * 2 teaspoons of honey

Treatment:

Other: D-xylose