Esophageal Atresia: Metaplasia, Barrett (Oesophagix)

University Hospital, Lille

Status: Completed

Conditions: Esophagus, Barrett; Gastroesophageal Reflux

Treatments: Procedure: esophageal biopsies

Study type: Observational

Funder types: Other

Identifiers

NCT02495051

2009/cic

DR-2011-057 / A 910270 (Other Identifier)

Details and patient eligibility

About

The frequency of Barrett's esophagus (BE) has increased in adults in the last decades, but BE is rare in children. Esophageal atresia (EA), the most common congenital anomaly affecting the esophagus, predisposes the patient to severe and prolonged gastroesophageal reflux disease. Because gastroesophageal reflux disease plays a major role in the development of BE by causing repeated mucosal damage, development of BE is a concern even in children and young adults in this specific population. The aim of this study is to assess the prevalence of BE (gastric and/or intestinal metaplasia) in a population of adolescents/young adults who had been treated for EA in early infancy. All eligible patients received upper gastrointestinal endoscopy under general anesthesia with standardized esophageal staged biopsies. Histological suspicion of metaplasia was confirmed centrally.

Enrollment: 120 patients

Sex: All

Ages: 15 to 19 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Medical history of esophageal atresia (all types, Ladd's classification)

Exclusion criteria

• No medical history of esophageal atresia
• Non acceptance to participate from the patient and/or his parents
• esophageal atresia treated with esophageal replacement (e.g., coloplasty, gastric transposition)

Trial design

120 participants in 1 patient group

single group-study

Treatment:

Procedure: esophageal biopsies