Esophageal Motility and Airway Defenses Among Infants

National Institutes of Health (NIH)

Status: Completed

Conditions: Perinatal Asphyxia; Infant, Premature, Diseases; Congenital Abnormalities

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00062452

R03DK061502 (U.S. NIH Grant/Contract)

EMADAI (completed)

Details and patient eligibility

About

Feeding difficulties and airway related consequences contribute significantly to the infant mortality and morbidity. Some of these problems may be dependent on neural control and muscular function. Prematurity, congenital anomalies and perinatal depression represent three important conditions in infants, that may have feeding and airway difficulties.Development of motility of the foregut and the adaptation during normal and disease in developing infants is unclear.

Full description

With the aid of small clinical research funding from the NIDDK, in this proposal, we have developed methods to safely evaluate foregut motility in relation to breathing among high risk infants. We are using simultaneous esophageal motility studies, swallowing and respiratory measurements in this evaluation.

Enrollment: 65 patients

Sex: All

Ages: 2 weeks to 6 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Prematurely born infants, Infants with congenital foregut anomalies, Infants with perinatal asphyxia, Ability to maintain vital signs at study,

Exclusion criteria

No contraindication to enteral feeding

Trial design

65 participants in 1 patient group

A-1,2,3

Description:

The cohort (A) comprised of high risk infants. There were 3 sub groups studied within this cohort: (1) premature infants, (2) Infants with congenital gut anomalies, and (3) perinatal asphyxia.