Esophageal Motility in Eosinophilic Esophagitis Evaluated by High Resolution Manometry. (HIMEOS)

Technical University of Munich

Status: Unknown

Conditions: Eosinophilic Esophagitis

Treatments: Device: High resolution manometry (HRM)

Study type: Interventional

Funder types: Other

Identifiers

NCT02331849

HIMEOS-2013

Details and patient eligibility

About

Esophageal Motility in eosinophilic esophagitis will be evaluated by High Resolution Manometry before and after medical treatment - motility is suspected to change/improve after therapy.

Full description

After identification of eosinophilic inflammation of the esophagus -> differentiation between GERD and eosinophilic esophagitis (via pH/MII-measurements or PPI-trial) -> High-resolution manometry (HRM) for evaluation of esophageal motility in patients with eosinophilic esophagitis (exclusion of GERD-patients)-> initiation of budesonide-therapy -> after eight weeks of therapy reevaluation of esophageal motility by HRM

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients with eosinophilic inflammation of the esophagus

Exclusion criteria

• refusal to participate in study
• pregnancy
• eosinophilic gastroenteritis
• Achalasia
• contraindication for gastroscopy / HRM / 24-h-pH/Impedance-monitoring
• contraindication for therapy with budesonide
• eosinophilic inflammation due to GERD

Trial design

20 participants in 1 patient group

Eosinophilic esophagitis

Other group

Description:

Patients with eosinophilic esophagitis after exclusion of GERD

Treatment:

Device: High resolution manometry (HRM)