Establishing Daily Applicable Parameters for Using Magnetic Resonance Spectroscopy of Spinal Cord

M.D. Anderson Cancer Center

Status: Enrolling

Conditions: Spinal Cord

Treatments: Diagnostic Test: Magnetic Resonance Spectroscopy (MRS) Scan

Study type: Interventional

Funder types: Other

Identifiers

NCT06548776

NCI-2024-06761 (Other Identifier)

2024-0249

Details and patient eligibility

About

To learn if MRS can effectively assess spinal cord lesions.

Full description

Primary Objective:

Establish the feasibility and spectrum of MRS for adult patients while mapping the total spine spectrum at short TEs to allow for future comparison with patients to assess spinal cord lesions malignant potential and grade.

Secondary Objective:

Test success of the spectrum by implementing the protocol on 3 low volume LMD receiving LMD receiving CSI. This will allow us to test reproducibility of the protocol and test effect of radiation on spinal cord at different time frames. This will serve as secondary data for subsequent trials targeting functional statues after radiation and tumor grading predictability of MRS.

Enrollment: 13 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Volunteers:

• Adults > 18 years
• Healthy with no malignancy, demyelinating disease, back pain, degenerative disease, or spinal cord lesions.
• Consent able patients.

Patients with low volume LMD to receive treatment CNS radiation:

• Adults > 18 years old.
• MR or CSF with evidence of LMD.
• Patients to receive CSI as part of standard treatment of LMD disease.
• Consent able patients, willingness and ability to comply with the study procedures.
• No spinal cord lesions only LMD disease
• Recruitment by radiation oncology faculty in consultation with Dr. De. . .

Exclusion criteria

Volunteers:

• Age < 18 years
• Pregnant or breastfeeding individuals.
• History of cancer.
• History of spinal cord lesions including malignant, demyelinating, or inflammatory.
• History of prior spinal surgery.
• History of implantable devices.
• History of MR claustrophobia.
• Degenerative disease or spinal/back pain including myelopathy and radiculopathy.
• Scoliosis.

Patients with LMD:

• Age < 18 years
• History of spinal cord lesions including malignant, demyelinating, or inflammatory.
• History of prior spinal surgery.
• History of implantable devices.
• History of MR claustrophobia.
• Degenerative disease or spinal/back pain including myelopathy and radiculopathy.
• Scoliosis.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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13 participants in 2 patient groups

Healthy Volunteers

Experimental group

Description:

Participants will be recruited from DI volunteer pool to implement MRS spine on.

Treatment:

Diagnostic Test: Magnetic Resonance Spectroscopy (MRS) Scan

Patients

Experimental group

Description:

Participants will be recruited from DI volunteer pool to implement MRS spine on.

Treatment:

Diagnostic Test: Magnetic Resonance Spectroscopy (MRS) Scan