Establishing the Diagnosis Standard and Analysis the Risk Factors of POI in Chinese Women

Nanfang Hospital, Southern Medical University

Status: Unknown

Conditions: Primary Ovarian Insufficiency

Study type: Observational

Funder types: Other

Identifiers

NCT03518918

NFEC-2016-141

Details and patient eligibility

About

The study aims to establishing the diagnosis standard of POI and analyzing the risk factors in Chinese women.

Full description

Premature ovarian insufficiency (POI) is a clinical syndrome defined by loss of ovarian activity before the age of 40 years. The POI guideline development group of ESHRE recommends the following diagnostic criteria: oligo/amenorrhea for at least 4 months and an elevated follicle stimulating hormone (FSH) level >25 mIU/mL on two occasion >4 weeks apart. But there still no diagnosis standard of POI in Chinese.The study aims to establishing the diagnosis standard of POI and analyzing the risk factors in Chinese women.

Enrollment: 50,000 estimated patients

Sex: Female

Ages: 12 to 39 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infertility
• The length of menstrual cycle longer than 35 days or shorter than/amenorrhea
• Serum FSH levels ≥10mIU/ml/ serum AMH levels ≤1.0pg/ml/ AFC ≤7, on at least two occasion >4 weeks apart

Exclusion criteria

• Polycystic Ovarian Syndrome
• other causes of amenorrhea