Establishing the Language Network With Independent Component Analysis of Resting State MRI (ICA Langage)

University Hospital, Angers

Status: Unknown

Conditions: Languages

Treatments: Device: MRI

Study type: Interventional

Funder types: Other

Identifiers

NCT02577757

CHU-Promoteur 2012-04

Details and patient eligibility

About

Proceed to an analysis of sensitivity and specificity results of the fMRI language network obtained in two ways: by providing a conventional language test and independent component analysis. These two methods will be compared to the reference method what the cortical intraoperative mapping.

Full description

Patients with brain tumors including malignant gliomas located in eloquent areas have long been considered inoperable because of median survival and predictable postoperative sequelae. The improved prognosis with chemoradiotherapy and surgical resection as complete as possible questioned this attitude. The goal is to operate those patients without additional disabilities. The cortical electrostimulation intraoperative mapping in awake surgery can meet the eloquent areas. Identifying with fMRI these same areas to better specify in advance the way initially and shortened the time to awake exploratory surgery which improves patient comfort. However anxiety induced by the review in a pre-operative setting, a debutante aphasia often make problematic the realization of a formal language test. The analysis in the low frequency of spontaneous oscillations of large neuronal networks can help isolate network of language at rest without particular language test at the group analysis. This methodology, however, needs to be validated at the individual level before it can be applied to pathology.

Proceed to an analysis of sensitivity and specificity results of the fMRI language network obtained in two ways: by providing a conventional language test and independent component analysis. These two methods will be compared to the reference method what the cortical intraoperative mapping.

Enrollment: 120 estimated patients

Sex: All

Ages: 7+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Persons major and minor.
• Having given their written consent, or whose parents have given their written consent for minors.
• Affiliated with the social security system
• All patients eligible adults in awake surgery
• Affiliated with the social security system
• patient given their written consent

Exclusion Criteria

• Contraindications to MRI
• Pregnant or breastfeeding women

Trial design

120 participants in 2 patient groups

healthy volunteers

Other group

Description:

achieving functional MRI

Treatment:

Device: MRI

Eligible patients with awakened surgery

Experimental group

Description:

achieving functional MRI

Treatment:

Device: MRI