Establishment and Characterization of Meningioma Patient-derived Organoids
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About
In this study, meningioma organoids will be established from patients' tissues and the characterization of the organoid will be performed.
Full description
Aims and Hypothesis to be tested:
The investigators hypothesized that the derived organoid should have a similar morphological and genetic mutation signatures to the patient primary tissue.
Study period: 1 year for patient recruitment and organoid generation from patient tumor
Study population: 30
Study samples:
Patient's meningioma tumor sample are collected from patients with surgical needs. Sample collected are used for organoid culture. Morphological and genetic characteristics will be compared between the patient tumor sample and the corresponding derived organoids
Primary outcome measures:
Whole exome sequencing data of patient tumor tissue and patients-derived organoids
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
- Adult patients (aged >18 years) with meningioma
- Admission into Prince Wales hospitals neurosurgical services
- Patients with surgical needs of meningioma removal
Exclusion criteria
- Patients (or next-of-kin as appropriate) refuse to participate into the study
Trial contacts and locations
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Central trial contact
Carol MF Chan
Data sourced from clinicaltrials.gov
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