Establishment of a Clinical and Prognostic Follow-up Cohort of Migraine Patients With Patent Foramen Ovale

Peking University

Status: Enrolling

Conditions: Migraine; Patent Foramen Ovale

Treatments: Procedure: Patent Foramen Ovale Closure; Drug: Conservative treatment; Drug: Antipaletet drug

Study type: Observational

Funder types: Other

Identifiers

NCT06953622

M2024296

Details and patient eligibility

About

To establish a headache center in China that combines clinical, imaging and laboratory examinations, explore the feasible treatment options for migraine combined with patent foramen ovale, and search for the possible influencing factors, construct models that influence prognosis.

Enrollment: 330 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Meet the diagnostic criteria for migraine in the International Classification of Headache (ICHD-3);
• Confirmation of patent foramen ovale through transthoracic echocardiography(TTE) or transesophageal echocardiography(TEE)/right heart contrast echocardiography
• Agree to participate in the study and sign the informed consent form.

Exclusion criteria

• Can not sign the informed consent form or cooperate with follow-up.

Trial design

330 participants in 3 patient groups

Conservative group

Description:

Don't use antiplatelet drugs or undergo patent foramen ovale closure.

Treatment:

Drug: Conservative treatment

Antiplatelet group

Description:

The application of antiplatelet drug.

Treatment:

Drug: Antipaletet drug

PFO group

Description:

Receive a patent foramen ovale closure surgery.

Treatment:

Procedure: Patent Foramen Ovale Closure