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Establishment of Clinical Prediction Model for Postoperative Symptomatic Spinal Epidural Hematoma

P

Peking University

Status

Not yet enrolling

Conditions

Spinal Epidural Hematoma

Treatments

Procedure: spinal surgery

Study type

Observational

Funder types

Other

Identifiers

NCT06633848
PekingUTH00238

Details and patient eligibility

About

The goal of this observational study is to establish a clinical prediction model based on artificial intelligence algorithms for patients with postoperative symptomatic spinal epidural hematoma(PSSEH) after spinal surgery. The investigators will collect the features of 2000 patients as the training set to train the models using AI algorithms, then recruit a prospective cohort of 2000 patients to test if the trained model is precise and consistent to predict the occurrence of PSSEH as well as to find out whether there is any new risk factor of PSSEH.

Full description

Firstly, the investigators plan to collect the features of 2000 patients who received spinal surgery at Peking University Third Hospital from January 2014 to December 2024, including those with PSSEH and the controls, as the training set to build up a prediction model based on multiple AI algorithms. Then, the investigators will choose the optimal model through comparing various features, assessing the robustness of the model quantitatively using k-fold cross validation and exploring the influence of all features on the output of the final model by means such as SHAP. Lastly, the investigators will recruit a prospective cohort of approximately 2000 patients who receive spinal surgery from January 2025 to December 2026 at Peking University Third Hospital and collect the same features as the training set to test if the trained prediction model is precise and consistent to predict the occurrence of PSSEH and whether there is any feature , undiscovered before, that is strongly related to PSSEH.

Enrollment

2,000 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

  • patients who will receive spinal surgery from January 2025 to December 2026 at Peking University Third Hospital

Exclusion criteria

  • patients with a history of lumbar trauma before admission;
  • patients who suffer from malignant tumor;
  • patients with systemic infection;
  • patients who quit the study midway

Trial contacts and locations

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Central trial contact

Orthopedics Department of Peking University Third Hospital

Data sourced from clinicaltrials.gov

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