Establishment of Human Lung Stem Cell Proliferation System and Organoid Construction in COPD

China-Japan Friendship Hospital

Status: Enrolling

Conditions: Chronic Obstructive Pulmonary Disease

Study type: Observational

Funder types: Other

Identifiers

NCT06275230

ZRJY2021-BJ08-02-07

Details and patient eligibility

About

The goal of this study is to proliferate human lung stem cell in vitro in order to establish a lung organoid derived from patients with COPD. The main question it aims to answer are:

• Can human lung stem cell proliferate in vitro.
• Can a lung organoid derived from patients with COPD be established. Participants will be sampled during pulmonary bronchoscope for organoid establishment.

Enrollment: 30 estimated patients

Sex: All

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1. Age under 55, regardless of gender
• 2. Patients with COPD lung disease who are going to undergo bronchoscopic biopsy
• 3. No genetic diseases and other respiratory diseases

Exclusion criteria

• Other conditions determined by the investigators to be unsuitable for inclusion, such as difficult sampling, difficult follow-up, and complicated with other serious diseases

Trial design

30 participants in 1 patient group

chronic obstructive pulmonary disease

Description:

Patients with COPD undergoing bronchoscope.