Estimate of the Activity and the Forecast of the Lupus Disease of the Adult by a Transcriptomic Score (STUDY LU-PUCE)

Public Assistance-Hospitals of Marseille (AP-HM)

Status: Completed

Conditions: Lupus Disease

Treatments: Biological: blood sample

Study type: Interventional

Funder types: Other

Identifiers

NCT00920114

2009-A00257-50

2009/04

Details and patient eligibility

About

Lupus erythematosus systemic is an auto-immune disease the evaluation of the activity of which remains very difficult because of an heterogeneousness of the clinical and biological symptoms. The aim of this study is to develop objective, specific and not invasive methods of evaluation of the activity and the forecast of the disease by using an analysis of the transcriptome on circulating blood. A transcriptomic analysis will be realized in parallel by the usual clinico-biological follow-up at the patients affected by systemic lupus, while the diagnosis before treatment, then during every revaluation of the disease during the period of the study. The already treated patients can also be included in this study.

Enrollment: 80 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Lupus disease diagnosed for lupus disease arm
• Signed assent

Exclusion criteria

• non-compliance
• pregnancy
• persons without social coverage

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 3 patient groups

Lupus disease

Experimental group

Treatment:

Biological: blood sample

Healthy witnesses

Active Comparator group

Treatment:

Biological: blood sample

Healthy witnesses with an other auto-immune disease

Active Comparator group

Treatment:

Biological: blood sample