Estimated Cumulative Incidence of Zika Infection at the End of the First Epidemic in the French West Indies in a Sample of Patients Followed for HIV Infection. (ZIKAVIH)

University Hospital Center of Martinique

Status: Terminated

Conditions: HIV Infections; Zika Virus Infection

Treatments: Other: Biological sample collection

Study type: Interventional

Funder types: Other

Identifiers

NCT03161444

16/B/06

2016-A01173-48 (Other Identifier)

Details and patient eligibility

About

This study will estimate the cumulative incidence of Zika infection at the end of the first epidemic in the French West Indies in a sample of patients followed for HIV infection.

Full description

Zika virus infection is expanding in all tropical and subtropical areas. The presence of Aedes albopictus in southern France raises concerns about the occurrence of outbreaks of indigenous Zika virus transmission. In this context, knowledge of the cumulative impact of the epidemic that affected the Caribbean in 2016 is an important issue for the management of future epidemics and modeling work. Since the Zika virus has not yet been circulated in the Lesser Antilles, the cumulative incidence rate can be estimated by conducting a general population seroprevalence survey at the end of the epidemic, or more simply within a cohort of patients regularly monitored and whose habitat is distributed throughout the study area. Thus, HIV-infected patients who benefit from regular clinical biological monitoring constitute a population sample perfectly adapted to the study of the emergence of the Zika virus in the French West Indies. The cumulative incidence of infection with the chikungunya virus after the 2014 epidemic has thus been estimated at 58% for Martinique and Guadeloupe using this method.

Enrollment: 354 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult (> 18 years pold)
• Followed for HIV infection at the 2 investigators centers (1 located at Martinique and 1 at Guadeloupe)
• Resident in Martinique /Guadeloupe (French West Indies) betwwen 01JAN2016 and 31DEC2016
• Affiliate or beneficiary of a social security scheme.
• Informed consent signed by the patient

Exclusion criteria

• Patient who has stayed in another area at risk of transmission of the Zika virus

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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354 participants in 1 patient group

Elective patient

Other group

Description:

Patient who has patricipated to the study CHIKVIH (NCT02553369) will have a blood collection during a follow up visit for HIV infection.

Treatment:

Other: Biological sample collection