Estimation of Dynamics of Humoral and Cellular Immunity in COVID-19 Patients

Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus

Status: Completed

Conditions: Covid19

Treatments: Diagnostic Test: Humoral and cellular immunity

Study type: Observational

Funder types: Other

Identifiers

NCT04649840

IBCE_COVID19_Immunity

Details and patient eligibility

About

The goal of the project: to study the dynamics of the humoral and cellular immunity in patients after pneumonia caused by the SARS-CoV-2 virus at different time intervals, in order to predict the duration of immune protection

Full description

• to form study groups of patients (at least 60 patients in total) who have recovered from pneumonia of varying severity caused by the SARS-CoV-2 virus (at least 30 patients in each of the groups of patients who have had pneumonia in moderate and severe forms);
• to investigate the parameters of cellular immunity (the content of antigen-specific T-cells to the main viral antigens - proteins S, N, M) in patients of different groups included in the trials, in dynamics 3, 6, 9 and 12 months after the COVID-19-associated pneumonia;
• to investigate the indicators of humoral immunity (the content of IgG to the main viral antigens - proteins S, N, M) in patients of different groups included in the trials, in dynamics 3, 6, 9 and 12 months after the COVID-19-associated pneumonia.

Enrollment: 274 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients recovered from the COVID-19 associated pneumonia (moderate and severe) in 1-3 month interval before inclusion into the trial;

Exclusion criteria

• cancer;
• drug and alcohol addiction;
• autoimmune diseases.

Trial design

274 participants in 2 patient groups

COVID-19 moderate

Description:

moderate COVID-19 associated pneumonia

Treatment:

Diagnostic Test: Humoral and cellular immunity

COVID-19 severe

Description:

severe COVID-19 associated pneumonia

Treatment:

Diagnostic Test: Humoral and cellular immunity