Estimation of Glomerular Filtration Flow in Patients of Resuscitation Under Extra-bodily Assistance (CREA-ECMO)

Toulouse University Hospital

Status: Unknown

Conditions: Extracorporeal Membrane Oxygenation Complication

Treatments: Diagnostic Test: Ultrasound for renal resistivity index measurement

Study type: Interventional

Funder types: Other

Identifiers

NCT03525483

2018-A00907-48 (Other Identifier)

RC31/18/0127

Details and patient eligibility

About

The aim of the study will be to evaluate the quality of the GFR estimate of the two estimation equations (CKD-EPI and Cockcroft's formula) against the measured clearance of creatinine, which can be performed routinely in intensive care.

To determine the proportion of patients with ARC under ECMO VV or VA and determine changes in renal vascular resistance index as a function of GFR level in patients with pulsatile cardiac output.

Full description

Extracorporeal assistance is recommended for patients with a potentially reversible acute risk of life that does not respond to conventional treatments. Hypoxic refractory syndromes, such as acute respiratory distress syndrome, are referred to as veno-venous ECMO (for Extracorporeal Membrane Oxygenation) (ECMO VV), whereas terminal cardiac dysfunctions require veno-arterial ECMO (VA ECMO). recovery of function (cardiotropic intoxication), or in the most severe cases, pending transplantation or long-term assistance.

This is a qualified pilot study, as it is the first one interested in evaluating the quality of the GFR estimate of the two estimation equations (CKD-EPI and Cockcroft formula) by relative to the measured clearance of creatinine, a method that can be performed routinely in intensive care, for resuscitation patients under veno-arterial or veno-venous ECMO.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients over 18
• ECMO VV or VA after 48 hours of installation
• Hemodynamic stability for at least 12 hours
• Person affiliated or benefiting from a social security scheme
• Having expressed an express consent OR patient for whom a relative has given express consent

Exclusion criteria

• Hemodynamic instability
• Chronic renal failure patients receiving dialysis
• Need for continuous or intermittent extra-renal cleansing
• Patients under the protection of justice
• Person participating in another search including an exclusion period still in progress
• Pregnant or lactating woman

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

100 participants in 1 patient group

Patients with ECMO

Experimental group

Description:

Patients with circulatory assistance by ECMO Patients are included 48 hours after ECMO VA or VV therapy and after hemodynamic stabilization defined by blood pressure stability and cardiac output for at least 12 hours without significant changes in amine flow. When stable they will have an Ultrasound for renal resistivity index measurement

Treatment:

Diagnostic Test: Ultrasound for renal resistivity index measurement