Estimation of Glomerular Filtration Rate (GFR) in Patients With Type 2 Diabetes Mellitus.

AHEPA University Hospital

Status: Unknown

Conditions: Diabetic Nephropathy; Diabetes Mellitus

Study type: Observational

Funder types: Other

Identifiers

NCT01215994

AHEPA

Details and patient eligibility

About

The purpose of the present study is to evaluate bias, precision and accuracy of new cystatin C and creatinine based equations for GFR estimation compared with 51Cr-EDTA (chromium-51 labeled ethylenediamine tetraacetic acid) measured GFR in patients with diabetes.

Full description

The purpose of the present study is to evaluate bias, precision and accuracy of new cystatin C and creatinine based equations for GFR estimation compared with 51Cr-EDTA measured GFR in patients with diabetes.

Additional, we will check which equation detects better the reduction of renal function over the time, in patients with diabetes.

Finally, we will investigate if cystatin C levels can be influenced by factors other than GFR

Enrollment: 600 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Type 2 and type 1 diabetes mellitus

Exclusion criteria

• Patients with other type diabetes: gestational, exocrine pancreatic defects, endocrinopathies, drugs
• Patients with end-stage renal disease, cardiac failure, hepatic failure, malignancies, immunosuppression, pregnant, diabetic ketoacidosis