Estimation of Pulmonary Capillary Blood Volume in Pre- and Postcapillary Pulmonary Hypertension

Medical University of Graz

Status: Completed

Conditions: Hypertension Pulmonary

Treatments: Other: assessment of DLNO and DLCO

Study type: Observational

Funder types: Other

Identifiers

NCT02789449

27-203 ex 14-15

Details and patient eligibility

About

The aim of the study is to investigate the role of the non-invasive assessment of nitric oxyde (NO) diffusion capacity (DLNO) in the differential diagnosis of different forms of pulmonary hypertension (PH). DLNO alone and in combination with the measurement of carbon monoxide (CO) diffusion capacity (DLCO) may help to differentiate between pre- and postcapillary forms of pulmonary hypertension. This hypothesis is based on the fact that NO has a much higher affinity to hemoglobin as compared to CO and may therefore its decrease may more specifically identify the limiting factors between the alveolar space and the lung capillaries including left heart failure (cardiac edema).

As there are no available published data yet to answer this question investigators aim to perform a small pilot study. The results of this study may allow the planning of a prospective study.

Enrollment: 17 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients undergoing right heart catheterization
• patients with clear precapillary PH (PAWP<12mmHg) or clear postcapillary PH (PAWP>18mmHg)
• signed informed consent

Exclusion criteria

• patients unable to perform the DLCO test

Trial design

17 participants in 2 patient groups

precapillary

Description:

patients with PH and PAWP\<12mmHg

Treatment:

Other: assessment of DLNO and DLCO

postcapillary

Description:

patients with PH and PAWP\>18mmHg

Treatment:

Other: assessment of DLNO and DLCO