Estimation of the Placental Volume by 3D Ultrasound at 12, 16 and 22 Weeks : Relation With Growth Factors and D-Dimers (VOLUPLA)

Centre Hospitalier Universitaire de Saint Etienne

Status: Completed

Conditions: Placenta Vascular Malformation

Treatments: Other: blood sample

Study type: Observational

Funder types: Other

Identifiers

NCT00767182

DGS2008-0193 (Other Identifier)

0808025

2008-A00233-52 (Other Identifier)

Details and patient eligibility

About

Pregnancy complications called PVP are mainly responsible for perinatal mortality. In these cases, the placenta is smaller and often the centre of thrombotic lesions. The estimation of the placenta volume by 3D ultrasound coupled with growth factors and D-Dimers measures could improve the understanding of these pathologies to optimize their detection.

Full description

Pregnancy complications called Placental Vascular Pathologies (PVP) are mainly responsible for perinatal mortality. In these cases, the placenta is smaller and often the centre of thrombotic lesions. The estimation of the placenta volume by 3D ultrasound coupled with growth factors and D-Dimers measures could improve the understanding of these pathologies to optimize their detection. Thus, the identification of predictive factors of the risk of occurrence or recurrence of PVP could allow us to propose a monitoring of patients at risk, to anticipate corticoids administration for the foetuses pulmonary maturation and perhaps later to adapt anti hypertensive and antithrombotic therapeutics.

Enrollment: 40 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• previous history of one or more PVC episodes : preeclampsia, HELLPs, retroplacental hematoma, vascular IUGR<10th percentile, recurrence miscarriage >2, unexplained IUFD or IUFD after abruption placentae, eclampsia.
• coming for a 12 weeks ultrasound

Exclusion criteria

• Multiple pregnancy
• past history of in utero fetal death due to congenital malformations, rhesus incompatibility or an infection
• previous history of IUGR which etiology was a chromosomal, genic or infectious anomaly

Trial design

40 participants in 1 patient group

Pregnant patients with VPP antecedent

Description:

Pregnancy women consulting for an scan during their 12th week of amenorrhea at the University Hospital of Saint Etienne will be studied in this clinical trial. They have an history of VPP (Vascular Placental Pathology). They will have to give a blood sample.

Treatment:

Other: blood sample