Estradiol and Testosterone Levels in Seminal Plasma of Men With Non-obstructive Azoospermia

University Hospital, Clermont-Ferrand

Status: Completed

Conditions: Non-obstructive Azoospermia With Testicular Biopsy for Spermatozoa Extraction

Treatments: Other: ESTRADIOL

Study type: Observational

Funder types: Other

Identifiers

NCT02255396

CHU-209

Details and patient eligibility

About

Estradiol and Testosterone are two important hormones for the regulation of an effective spermatogenesis in human testis. The evaluation of levels of estradiol and testosterone in seminal plasma of men with non-obstructive azoospermia may be a predictive test before surgical testicular biopsy to determine the chance of a positive sperm extraction to use for ICSI.

Full description

The aim of this study is to compare the levels of esttradiol and testosterone in seminal plasma of men with non-obstructive azoospermia. Indeed, for these patients, none biological test allows to predict a positive sperm extraction before the surgical testis biopsy is performed. Since the involvement of estradiol and testosterone in the regulation of spermatogenesis, the measurement of these hormones in seminal plasma may be a predictive tool for these men before testis biopsy.

Enrollment: 50 patients

Sex: Male

Ages: 18 to 55 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Azoospermia confirmed by two semen analysis (at minimum 74 days between the both analysis)
• Volume of seminal plasma >0.6ml
• Testicular biopsy one month after the last semen analysis
• Informed consent signed by the patient

Exclusion criteria

• obstructive azoospermia
• cryptozoospermia