Estrogen Hormone Protocol

National Institutes of Health (NIH)

Status and phase: Completed; Phase 3

Conditions: Alzheimer Disease

Treatments: Drug: Estrogen

Study type: Interventional

Funder types: NIH

Identifiers

NCT00000177

3U01AG010483-08S2 (U.S. NIH Grant/Contract)

IA0001

Details and patient eligibility

About

Estrogen is a hormone that is dominant in the female reproductive system. In women, most estrogen is produced by the ovaries. Men produce estrogen by converting testosterone into estrogen. Because this hormone also has many beneficial effects on brain cells, it currently is being studied as a treatment for Alzheimer's disease. The enzyme that forms the neurotransmitter acetylcholine is promoted in the presence of estrogen. Several very small clinical studies have demonstrated improvement in cognitive function and mood measures in women with Alzheimer's disease who take estrogen.

Sex: Female

Ages: 60+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Women with a diagnosis of Alzheimer's disease who currently are not taking estrogen replacement therapy, who have had a hysterectomy, and who are in stable general health.

Exclusion criteria

• Patients with an uncontrolled health problem, such as untreated high blood pressure or thyroid disease.