Estrogen Hormone Protocol

National Institutes of Health (NIH) logo

National Institutes of Health (NIH)

Status and phase

Completed
Phase 3

Conditions

Alzheimer Disease

Treatments

Drug: Estrogen

Study type

Interventional

Funder types

NIH

Identifiers

NCT00000177
3U01AG010483-08S2 (U.S. NIH Grant/Contract)
IA0001

Details and patient eligibility

About

Estrogen is a hormone that is dominant in the female reproductive system. In women, most estrogen is produced by the ovaries. Men produce estrogen by converting testosterone into estrogen. Because this hormone also has many beneficial effects on brain cells, it currently is being studied as a treatment for Alzheimer's disease. The enzyme that forms the neurotransmitter acetylcholine is promoted in the presence of estrogen. Several very small clinical studies have demonstrated improvement in cognitive function and mood measures in women with Alzheimer's disease who take estrogen.

Sex

Female

Ages

60+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Women with a diagnosis of Alzheimer's disease who currently are not taking estrogen replacement therapy, who have had a hysterectomy, and who are in stable general health.

Exclusion criteria

Patients with an uncontrolled health problem, such as untreated high blood pressure or thyroid disease.

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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