Ethanol Lock and Risk of Catheter Related Blood Stream Infection in Patients With Haemodialysis Catheter

Zealand University Hospital

Status: Active, not recruiting

Conditions: Hemodialysis Complication; Hemodialysis Catheter-Associated Bacteremia

Treatments: Drug: Isotonic saline with heparin; Drug: Ethanol 70%

Study type: Interventional

Funder types: Other

Identifiers

NCT05953675

REG-184-2017

Details and patient eligibility

About

The aim of this study is to examine the effect of ethanol (70%) as lock-solution after hemodialysis on:

• The frequency of dialysis catheter-related bacteremia among patients under observation of potential complications
• Other complications of the use of hemodialysis-catheters eg. dysfunction of the catheter due to thrombosis.

Enrollment: 280 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age at or above 18 years.
• Currently recieving hemodialysis treatment with tunneled intravenous hemodialysis-catheter
• Written informed consent after verbal and written information is given.

Exclusion criteria

• Pregnancy or breastfeeding
• Intolerance to ethanol or contraindications for the use of ethanol. Eg. possible interactions, former alcohol dependency.
• Earlier infections to current catheter (exit-site, tunnel-infection and catheter-related bloodstream infection

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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280 participants in 2 patient groups

Control arm

Active Comparator group

Description:

Standard procedure of isotonic saline with heparin as lock-solution

Treatment:

Drug: Isotonic saline with heparin

Intervention arm

Experimental group

Description:

3 mL of 70% ethanol as lock-solution

Treatment:

Drug: Ethanol 70%