Etiological DiagnOsis of caRdiac Diseases Based on echoCardiograpHIc Images and Clinical Data. (ORCHID)

Civil Hospices of Lyon

Status: Enrolling

Conditions: Hypertension Arterial; Left Ventricular Hypertrophy; Cardiomyopathies; Hypokinetic

Treatments: Other: Determine the etiology of hypokinetic and hypertrophic heart disease on transthoracic echocardiography data alone

Study type: Observational

Funder types: Other

Identifiers

NCT05942729

69HCL22_0819

Details and patient eligibility

About

Research hypothesis - Recent studies have shown that high-dimensional descriptors of the cardiac function can be efficiently exploited to characterize targeted pathologies. In this project, the investigators hypothesize that echocardiograms possess a wealth of information that is currently under-exploited and that, combined with relevant patient data, will allow the development of robust and accurate digital tools for etiological diagnosis.

Objectives - Based on key advances recently obtained in image analysis, notably by members of the consortium, the objective of this project is to develop rigorous and explainable cardiac disease prediction models from echocardiography based on the transformer paradigm (AI). The strength of this study lies in the development of a strong AI framework to model the complex interactions between high-quality image-based measurements extracted from echocardiograms and relevant patient data to automatically predict etiological diagnosis of cardiac diseases

Enrollment: 1,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with transthoracic echocardiography with satisfactory image quality (sufficient echogenicity)

Exclusion criteria

• Minor patients
• Patients under curatorship or guardianship

Trial design

1,000 participants in 2 patient groups

Patients with hypokinetic cardiomyopathy.

Description:

The first arm includes patients with hypokinetic cardiomyopathy for whom echocardiographic data do not readily distinguish between a cause related to coronary artery disease or related to primary myocardial dysfunction, requiring invasive intervention, i.e., coronary angiography.

Treatment:

Other: Determine the etiology of hypokinetic and hypertrophic heart disease on transthoracic echocardiography data alone

Patients with left ventricular hypertrophy related to hypertension/infiltrative myocardial disease

Description:

The second arm includes patients with left ventricular hypertrophy, whose aetiology may be various and whose workup is particularly extensive and expensive.

Treatment:

Other: Determine the etiology of hypokinetic and hypertrophic heart disease on transthoracic echocardiography data alone