Etiology of Lymphopenia in Covid19 Infection

Dr Medhat Khafagy

Status: Completed

Conditions: Lymphopenia

Treatments: Diagnostic Test: Complete blood picture, bone marrow aspiration cytology

Study type: Observational

Funder types: Other

Identifiers

NCT04404608

201920008.2

Details and patient eligibility

About

Study of the cause of lymphopenia in Covid19 viral infection will be done in 3 cohorts. First cohort will be patients asymptomatic or with mild symptoms. Second cohort will be patients with severe illness and admitted to ICU. Third cohort will be patients critically ill and on artificial ventilation.

Full description

Each cohort will include 30 patients. Complete blood count in all patients will be done daily in all patients. Bone marrow aspiration cytology will be done in some selected patients especially those with lymphopenia less than 1000 per cubic mm.

Correlation of the degree of lymphopenia with the status of the patients will be done. Also correlation will be done about the relation of recovery of lymphopenia and status of the patients.

Enrollment: 172 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any patient admitted with the diagnosis of Covid19 viral infection

Exclusion criteria

• Any patient who died within one day of admission

Trial design

172 participants in 3 patient groups

Asymptomatic or mild symptoms patients patients

Description:

Patients with no or mild symptoms and need no respiratory support.

Treatment:

Diagnostic Test: Complete blood picture, bone marrow aspiration cytology

Severe symptoms patients

Description:

Patients who need admission to ICU because he needs oxygen by nasal canula and needs drugs whether azthromycin or remdesivir according to treatment protocol.

Treatment:

Diagnostic Test: Complete blood picture, bone marrow aspiration cytology

Critically ill patients

Description:

Patients who need artificial ventilation because of many causes and may need plasma from convalescent patients

Treatment:

Diagnostic Test: Complete blood picture, bone marrow aspiration cytology