Etomidate and Esketamine on Postoperative Pain After Tonsillectomy Undergoing Children

Anqing Municipal Hospital

Status: Not yet enrolling

Conditions: Esketamine; Etomidate; Children; Tonsillectomy

Treatments: Drug: Etomidate and esketamine group; Drug: Etomidate and fentanyl group

Study type: Interventional

Funder types: Other

Identifiers

NCT07062601

Xuzhang0109

Details and patient eligibility

About

Objective: To explore the effect of etomidate and esketamine on postoperative pain after tonsillectomy in children.

Methods: Investigators enrolled 64 children with American Society of Anesthesiologists (ASA) physical status I and II, aged 2-10 years, and scheduled for elective undergoing tonsillectomy with general anesthesia. All the enrolled patients were randomly divided into etomidate and fentanyl group (Group A) and etomidate and esketamine group (Group B). In the etomidate-fentanyl group (group A), 0.3 mg/kg etomidate and 4 µg/kg fentanyl were given at the induction of anesthesia, followed by continuous infusion of propofol at 4-12 mg/kg/h and remifentanil at 3-6 µg/kg/h until the end of the surgery, respectively; in the etomidate-esketamine group (group B), induction of anesthesia with 0.3 mg/kg etomidate and 0.5 mg/kg esketamine , followed by continuous infusion of propofol at 4-12 mg/kg/h and remifentanil at 3-6 µg/kg/h until the end of the operation. Anesthesiologists who were unaware of the grouping recorded the FlACC Pain Scale at 2 h, 8 h, and 24 h after surgery.

Enrollment: 64 estimated patients

Sex: All

Ages: 2 to 10 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children who underwent elective tonsillectomy
• Aged 2-10 years old
• ASA class I-II

Exclusion criteria

• Children with hepatic or renal dysfunction
• Those with increased intracranial or intra-ocular pressure
• Children with schizophrenia, bipolar disorder, and any other psychiatric condition
• Children with preexisting chronic pain
• Children with preoperative combined sinus bradycardia or atrioventricular block

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

64 participants in 2 patient groups

Etomidate and fentanyl group

Experimental group

Description:

In the etomidate-fentanyl group (group A), 0.3 mg/kg etomidate and 4 µg/kg fentanyl were given at the induction of anesthesia, followed by continuous infusion of propofol at 4-12 mg/kg/h and remifentanil at 3-6 µg/kg/h until the end of the surgery, respectively

Treatment:

Drug: Etomidate and fentanyl group

Etomidate and esketamine group

Experimental group

Description:

In the etomidate-esketamine group (group B), induction of anesthesia with 0.3 mg/kg etomidate and 0.5 mg/kg esketamine , followed by continuous infusion of propofol at 4-12 mg/kg/h and remifentanil at 3-6 µg/kg/h until the end of the operation

Treatment:

Drug: Etomidate and esketamine group