Etoposide Plus Cisplatin Compared With Temozolomide in Patients With Glioblastoma

Zhongnan Hospital

Status and phase

Not yet enrolling

Phase 2

Conditions

MGMT-Unmethylated Glioblastoma

Treatments

Drug: Etoposide Plus Cisplatin

Study type

Interventional

Funder types

Other

Identifiers

NCT05694416

FUTURE

Details and patient eligibility

About

Temozolomide provided significant and clinically meaningful benefit in MGMT gene promoter methylation glioblastoma. However, in unmethylated patients, the effect of Temozolomide is limited. The aim of this study is to compare the effect of Etoposide plus Cisplatin and Temozolomide in patients with MGMT gene promoter unmethylation glioblastoma.

Full description

60 Patients with glioblastoma were recruited for this study based on the following eligibility criteria: Age between 18 and 70, performance status of 0-1 (Eastern Cooperative Oncology Group performance status), histologically confirmed MGMT gene promoter unmethylation glioblastoma, no cerebrospinal fluid and distant metastatic disease. All patients had adequate hematologic, hepatic, and renal function. Patients younger than 18 years; patients with a prior (i.e. within 5 years) or synchronous malignancy, other than non-melanoma skin cancer; and those with significant comorbidities were excluded.

60 patients were randomly divided into two groups and compared the difference of efficacy between the two groups

Enrollment

60 estimated patients

Sex

All

Ages

18 to 70 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age between 18 and 70,
performance status of 0-1 (Eastern Cooperative Oncology Group performance status),
histologically confirmed MGMT gene promoter unmethylation glioblastoma
no cerebrospinal fluid and distant metastatic disease.
adequate hematologic, hepatic, and renal function

Exclusion criteria

younger than 18 years;
with a prior (i.e. within 5 years) or synchronous malignancy, other than non-melanoma skin cancer; and those with significant comorbidities