ETV Versus Shunt Surgery in Normal Pressure Hydrocephalus

Johns Hopkins University

Status: Terminated

Conditions: Hydrocephalus

Treatments: Procedure: Ventriculoperitoneal Shunt Placement; Procedure: Endoscopic Third Ventriculostomy(ETV)

Study type: Observational

Funder types: Other

Identifiers

NCT00946127

NA_00014030

Details and patient eligibility

About

The purpose of this study is to test and compare the efficacy of Endoscopic Third Ventriculostomy with shunting of Cerebrospinal fluid (CSF)for treatment for patients of Normal pressure Hydrocephalus.

Full description

Normal pressure Hydrocephalus is a reversible disorder of cognition and gait disorder.Currently the shunting of CSF is the recommended treatment of these patients. Even though shunts are known to be beneficial treatment of Hydrocephalus they often need treatment or revision for infection or malfunction. Endoscopic Third Ventriculostomy is a treatment without complications of shunt and is known to benefit obstructive forms of hydrocephalus.Few studies have also shown that it may be efficacious treatment Normal pressure Hydrocephalus.

Enrollment: 13 patients

Sex: All

Ages: 50+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Patients with NPH
• Meet at least 2 of 3 Hakim and Adams diagnostic criterion for NPH (dementia, gait instability and urinary incontinence)
• Ventriculomegaly defined by CT or MRI, Evans' index > 0.3
• Clinical improvement after 3 day trial of CSF drainage.
• MMSE>24
• Informed consent from patient

Trial design

13 participants in 2 patient groups

Shunt Arm

Description:

Ventriculoperitoneal Shunt

Treatment:

Procedure: Ventriculoperitoneal Shunt Placement

ETV arm

Description:

Endoscopic Third Ventriculostomy

Treatment:

Procedure: Endoscopic Third Ventriculostomy(ETV)