European CML Blast Crisis Register (BlastCrisis)

University of Jena

Status: Enrolling

Conditions: Chronic Myeloid Leukemia in Myeloid Blast Crisis

Study type: Observational

Funder types: Other

Identifiers

NCT03869502

BlastCrisis

Details and patient eligibility

About

Multicentric prospective and retrospective register collecting patient with CML blast crisis diagnosed in Germany and Europe

Full description

Since the advent of treatment with tyrosine kinase inhibitors (TKI), the incidence of blast crises has significantly decreased. Nevertheless, about 5% of patients diagnosed with chronic myeloid leukemia (CML) will evolve into a blast phase at some point during the course of their disease. Furthermore, despite the advances made in CML treatment, outcome of patients with blast crises are still dismal. Due to the rarity of this condition clinical trials are challenging, and collaboration between researchers both at national and international level is needed to collect a meaningful number of data.

Enrollment: 250 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age >18 years

• Diagnosis of BCR-ABL positive CML blast crisis according to the WHO criteria:

  • Blasts 20% or more of peripheral blood white cells or bone marrow cells or
  • Extramedullary blast proliferation or
  • Large foci or clusters of blasts in bone marrow biopsy

Exclusion criteria

• Lack of informed consent