EUS-FNI for Nonfunctional Pancreatic Neuroendocrine Tumors

Guangxi Medical University

Status: Enrolling

Conditions: Endoscopic Ultrasound; Pancreatic Neuroendocrine Tumor; Nonfunctional Pancreatic Neuroendocrine Tumor

Treatments: Procedure: EUS-guided lauromacrogol ablation; Procedure: EUS-guided ethanol ablation

Study type: Interventional

Funder types: Other

Identifiers

NCT05566093

2022-K039-01

Details and patient eligibility

About

The current study aims to access the feasibility, safety, and efficacy of EUS-FNI for nonfunctional pNETs

Full description

The management of nonfunctional pancreatic neuroendocrine tumors (NF-pNETs) remains controversial. In general, surgical resection is the standard treatment for NF-pNETs. However, the incidence of postoperative adverse events of surgical resection is relatively high. Recently, several studies have revealed that endoscopic ultrasonography (EUS)-guided fine-needle injection (EUS-FNI) with ethanol or lauromacrogol may offer an effective treatment for pNETs. Therefore, a multicenter prospective study is being conducted to further identify the efficacy and safety of EUS-FNI for NF-pNETs.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patients with NF-pNETs are evaluated by cytology or immunohistochemistry.
2. Patients who refuse surgery or observation.
3. Patients who have given their fully informed consent.

Exclusion criteria

1. Patients who are not suitable for EUS-FNI.
2. Patients who have poor conditions including blood coagulation dysfunction, mental disorders, and mild or severe cardiorespiratory.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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20 participants in 1 patient group

Nonfunctional pancreatic neuroendocrine tumors

Experimental group

Description:

The patients with NF-pNETs will undergo EUS-guided ethanol or lauromacrogol ablation

Treatment:

Procedure: EUS-guided ethanol ablation

Procedure: EUS-guided lauromacrogol ablation